Comparison of Platelet Rich Plasma and 10%Dextrose Solution Effect Towards Muscle Healing Process

Abstract

Both Platelet Rich Plasma (PRP) and Dextrose 10%have proliferated effect by promoting some growth factors. Using PRP and dextrose 10%intralesional injection in muscle injury were estimated faster and promote muscle quality. The experimental comparative study was conducted on 27 rats that have muscle injury grade 2, then divided into 3 groups. The first group was injection with PRP, the second group with dextrose 10%, the third group with NaCl 0.9% as a control group. After one week, the subjects were sacrificed, and their gastrocnemius muscle was examined to see the level of myoblast through the immunohistochemical technique. The results show an increased level of myoblast cell in PRP and a 10%dextrose group than control, and the level of myoblast cell was higher in the PRP group than the 10%dextrose group (PRP:10% Dextrose:0.9%NaCl=12,33:8,00:5,67). In conclusion, using PRP and 10%dextrose intralesional injection increase the level of myoblast cell in muscle injury grade 2, and using PRP was better than 10%dextrose.