Comparison of PiB-PET data to florbetapir-PET data acquired from cohorts at different research sites

Abstract

cholesterol, systolic blood pressure, diabetes and smoking) to cortical thickness. Cognition was evaluated using standardized composite scores of episodic memory and executive functions. Results: Among the FCRP factors, age (p 1⁄4.023) and HDL cholesterol (p 1⁄4.020) were correlated with cortical thickness. Both increased age and low HDL cholesterol were associated with thinner frontal and temporal cortex; low HDL was also associated with thinner parietal cortex. When subjects were divided by amyloid status, both high vascular risk (FCRP total score) and low HDL cholesterol were associated with thinner frontal and temporal cortex in both PIBand PIB+ subjects. In PIB+ subjects, high vascular risk and low HDL cholesterol were also associated with thinner parietal cortex (Figure). Finally, higher beta-amyloid and higher vascular risk were associated with lower memory performance and cortical thickness mediated these relationships. Conclusions: While vascular risk and HDL cholesterol affect cortical thickness in frontotemporal cortex regardless of amyloid status, individuals with beta-amyloid deposition show further involvement of parietal cortex. Furthermore, the data suggest that cortical thickness mediates the impact of vascular risk and beta-amyloid on memory function.