Abstract
Photo-optical TCpO2 (pTCpO2) has been proposed as a new method to determine the partial oxygen pressure of the lower extremity in patients with peripheral arterial disease. It is aimed to determine the level of agreement between pTCpO2 and the traditional electro-chemical transcutaneous oxygen tension measurement (eTCpO2). Eighteen patients with intermittent claudication underwent simultaneous ankle-brachial index measurement, toe-pressure, pTCpO2 and eTCpO2 tests. Oxygen tension levels were measured on anterior chest and calf prior in rest (T0), during induced ischemia (T1) and after blood flow restoration (T2). TCpO2 agreement was assessed according to the principles of Bland and Altman. Absolute average TCpO2 values differed between eTCpO2 and pTCpO2 for calf in T2 (38,1 mmHg (σ 14,4) vs. 49,8 (σ 22.3) with P=0.35). The Bland-Altman plots demonstrated eTCpO2 and pTCpO2 bias of 3,7 mmHg (σ 18,8), 11,6 mmHg (σ 17,6) and 6,7 mmHg (σ 23,5) for T0, T1 and T2 for the calf. pTCpO2 is in agreement with eTCpO2 in measuring pO2 levels of the lower extremity in rest and during induced ischemia in patients with vascular claudication. The large variability between eTCpO2 and pTCpO2 should be accounted for, while pTCpO2 values have a tendency to demonstrate higher values in comparison to eTCpO2.
Highlights
Electro-chemical transcutaneous oxygen tension measurement has been applied for for the lower extremity has been introduced.[5]
Significant difference was found between electro-chemical TCpO2 (eTCpO2) and Photo-optical TCpO2 (pTCpO2) mean value for calf in T2 (38,1 mmHg (σ 14,4) vs. 49,8 (σ 22,3) with P = 0.04)
BlandAltman plots demonstrate a bias between eTCpO2 and pTCpO2 for the anterior chest of 4,3 mmHg (σ 27,3), 6,2 mmHg (σ 18,9) and 7,1 mmHg (σ 23,6) and for the calf 3,7 mmHg (σ 18,8), 11,6 mmHg (σ 17,6) and 6,7 mmHg (σ 23,5) for T0, T1 and T2, respectively
Summary
Electro-chemical transcutaneous oxygen tension measurement (eTCpO2) has been applied for (pTCpO2) for the lower extremity has been introduced.[5] Photo-optical TCpO2 has been proposed as a more reliable form of TCpO2 as it does not consume nor extract oxygen.[2,6,7]. PTCpO2 is suggested to be more practical, primarily because it is less time consuming.[5]. PTCpO2 devices are significantly cheaper to purchase in comparison to eTCpO2 The level of agreement between the pTCpO2 and eTCpO2 remains unknown. To explore if real-time measurement of photo-optical TCpO2 is feasible when patients with peripheral arterial disease undergo a treadmill test and to demonstrate the level of agreement between pTCpO2 and eTCpO2 measurement we conducted a explorative comparative study
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