Comparison of Pharmacokinetics and Dynamics of the Long-Acting Insulin Analogs Glargine and Detemir at Steady State in Type 1 Diabetes: a Double-Blind, Randomized, Crossover Study

Abstract

We thank Dr. Banarer (1) for his appreciation of our work (2) and for the opportunity to discuss his criticism. The formula we used to describe the insulin activity profile was constructed to emphasize the ability of a basal insulin preparation to maintain plasma glucose at the target value during fasting, which is the clinical target of a basal insulin preparation. Accordingly, the second variable of the formula, plasma glucose concentration, was given greater power. The impact …