Abstract
This study aimed to optimize a method for determining N-ethyldiethanolamine (EDEA) and N-methyldiethanolamine (MDEA) in urine samples using gas chromatography-mass spectrometry. The analytes were derivatized with N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA) and the most proper organic solvent was investigated. Best recoveries were found for acetonitrile and dimethylsulphoxide. The recoveries of spiked samples (100 ng ml−1) were found as 108 ± 5.7% for EDEA and 97 ± 6.4 for MDEA. The limit of detection (LOD, S/N = 3) values were 0.5 ng ml−1 and 0.4 ng ml−1 for EDEA and MDEA, respectively. The precision of the method in terms of RSD was between 5–8%.
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