Comparison of Optical Coherence Tomography Angiography Findings in Patients with Behçet’s Disease and Healthy Controls

Abstract

ABSTRACT Purpose To investigate optical coherence tomography angiography (OCTA) findings in patients with Behçet’s disease (BD). Methods Ninety-four eyes of 49 patients with BD and 53 eyes of 53 healthy subjects were included. Vascular density (VD), foveal avascular zone (FAZ) area, perifoveal capillary hypoperfusion, perifoveal capillary network disorganization, and FAZ irregularity were analyzed. Results OCTA revealed retinal VD reduction and higher perifoveal capillary hypoperfusion, perifoveal capillary network disorganization and FAZ irregularity in ocular Behçet’s compared to nonocular Behçet’s (p = .000). However, compared to normal eyes, there was no difference between any OCTA measurements in nonocular BD patients. The mean area of FAZ was not different in any group (p = .266). In ocular Behçet, visual acuity was inversely correlated with FAZ area and FAZ irregularity. Conclusion Retinal VD decreases and perifoveal microvascular network changes in ocular Behçet’s. FAZ irregularity may be a more valuable marker than FAZ area for indicating ocular involvement.