Abstract
Although a significant proportion of type 2 diabetes mellitus (T2DM) cases arose from normal-weight individuals, studies on indicators of T2DM in normal-weight people are limited. Accordingly,this study aims to investigate the predictive value of obesity indices and triglyceride glucose-related parameters (TyG-related parameters) in T2DM among normal-weight Chinese elderly. A total of 24,215 normal-weight Chinese elderly (age ≥ 60years) [body mass index-BMI (18.5-23.9kg/m2)] were included. Obesity indices and triglyceride glucose-related parameters (TyG-related parameters) included waist circumference (WC), waist-to-height ratio (WHtR), visceral adiposity index (VAI), lipid accumulation product (LAP), and TyG-related parameters (TyG, TyG-BMI, TyG-WC, and TyG-WHtR). Multivariate logistic regression analysis was performed to examine the associations between obesity- and TyG-related indices and T2DM. The areas under the curve (AUC) of the receiver-operating characteristic (ROC) curve analyses were used to evaluate and compare the predictive value of the different indices. The prevalence of T2DM was 14.2% in normal-weight individuals. Among the indices, TyG was significantly associated with T2DM among men and women, respectively, (adjusted odds ratio-aOR per SD 3.46; 95% CI 3.23-3.71) and (aOR per SD 3.64; 95% CI 3.43-3.86). Compared with other indices, TyG had the highest AUC value for T2DM in men (AUC: 0.818, 95% CI 0.810-0.825) and women (AUC: 0.824, 95% CI 0.814-0.833). TyG is an effective marker and outperforms other indices when predicting T2DM in the normal-weight Chinese elderly population. Level V: Opinions of authorities, based on descriptive studies, narrative reviews, clinical experience, or reports of expert committees.
Highlights
Background : a significant proportion of type 2 diabetes mellitus (T2DM) cases arose from normal-weight individuals, studies on indicators that can predict T2DM in normal-weight people are limited
This study aims to investigate the predictive value of obesity indices and triglyceride glucose related parameters (TyG-related parameters) in T2DM among normal-weight Chinese elderly
Multivariate logistic regression analysis was performed to examine the associations between obesity-and Triglyceride Glucose (TyG)-related indices and T2DM
Summary
Abbreviations: T2DM,Type 2 Diabetes Mellitus; BMI , Body Mass Index; SBP, Systolic Blood Pressure, DBP, Diastolic Blood Pressure; TC, Total Cholesterol; TG, Triglyceride; HDL-C, high-density lipid cholesterol; LDL-C, low-density lipid cholesterol; FPG, fasting plasma glucose; WC, Waist Circumference; WHtR, Waist HeightRatio; VAI , Visceral Adiposity Index; LAP, Lipid Accumulation Product; TyG, Triglyceride Glucose; TyG-BMI, TyG related to BMI; TyG-WC, TyG related to WC; TyG-WHtR, TyG related to WHtR; Data are presented as means ± standard deviation, and interquartile range or frequencies. p values are from t-tests or Chi-square tests for analysis of variance for continuous variables and categorical variables
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