Comparison of Neutrophil to Lymphocyte Ratio (NLR) and Lymphocyte to Monocyte Ratio (LMR) values in controlled and uncontrolled Type 2 Diabetes Mellitus (T2DM) patient

Abstract

Background: Inflammation is related to insulin resistance. Neutrophil to Lymphocyte Ratio (NLR) and Lymphocyte to Monocyte Ratio (LMR) are used as inflammation markers and predictors of complications associated with diabetes. This study aims to determine the differences of NLR and LMR values in controlled and uncontrolled type 2 diabetes mellitus (DM) patients.Methods: A cross-sectional was conducted in this study at Sanglah General Hospital. Research data were taken from the Laboratory Information System (LIS) and medical records. NLR is obtained from the absolute neutrophils divided by absolute lymphocytes, LMR is obtained from absolute lymphocytes divided by absolute monocytes. Data were analyzed using SPSS version 25 for Windows.Results: Type 2 diabetes mellitus mainly was male (58.3%) with the highest proportion at the age of 46-55 years (50.0%). The mean leukocyte count was significantly higher in the uncontrolled group (8.45±1.58 cells/µL) (p<0.05). NLR showed a significant difference in the two groups (p<0.05). However, there was no significant difference in LMR between groups (p>0.05)Conclusion: NLR in uncontrolled type 2 DM was significantly higher than in controlled type 2 DM. Meanwhile, the LMR did not show a significant difference between the two groups.