Abstract
Background Negative pressure wound therapy (NPWT) with instillation and dwell time (NPWTi-d) includes periodic instillation of topical solution into the wound followed by a negative pressure. Our objective was to evaluate potential differences in wound outcomes in patients receiving NPWT and those receiving NPWTi-d using saline.MethodsAn analysis was performed using two previously published independent studies from a single investigator and hospital to compare patient characteristics and clinical outcomes of infected wounds from 74 NPWT-treated patients with 42 NPWTi-d-treated patients.Results Patient demographics and comorbidities, wound etiologies, and anatomical locations of wounds were similar between groups, although a significantly higher percentage of NPWT-treated patients had end-stage renal disease (P = 0.0119). Compared with patients treated with standard NPWT, NPWTi-d-treated patients had a significantly lower number of operations (P = 0.0048), shorter length of hospital stay (P = 0.0443), shorter time to final surgical procedure (P = 0.0001), higher percentage of closed wounds (P = 0.0004), and a higher percentage of wounds that remained closed at one month (P = 0.0001).ConclusionsThe results of this analysis suggest that management of infected wounds with NPWTi-d using saline leads to favorable wound outcomes when compared to those managed with NPWT.
Highlights
Increased patient morbidity and mortality, length of hospital stay, and costs are associated with infection in both acute and chronic wounds [1]
Compared with patients treated with standard Negative pressure wound therapy (NPWT), NPWT with instillation and dwell time (NPWTi-d)-treated patients had a significantly lower number of operations (P = 0.0048), shorter length of hospital stay (P = 0.0443), shorter time to final surgical procedure (P = 0.0001), higher percentage of closed wounds (P = 0.0004), and a higher percentage of wounds that remained closed at one month (P = 0.0001)
The results of this analysis suggest that management of infected wounds with NPWTi-d using saline leads to favorable wound outcomes when compared to those managed with NPWT
Summary
Increased patient morbidity and mortality, length of hospital stay, and costs are associated with infection in both acute and chronic wounds [1]. NPWT has evolved to include the periodic instillation of topical wound solutions directly over the wound bed, followed by removal using negative pressure. This NPWT with instillation and dwell time (NPWTi-d) utilizes the same properties of NPWT with the added benefit of wound cleansing [6]. Our objective was to evaluate potential differences in wound outcomes in patients at an institution receiving NPWT and those receiving NPWTi-d with saline. Negative pressure wound therapy (NPWT) with instillation and dwell time (NPWTi-d) includes periodic instillation of topical solution into the wound followed by a negative pressure. Our objective was to evaluate potential differences in wound outcomes in patients receiving NPWT and those receiving NPWTi-d using saline
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