Abstract
We compared the levels of muscle strength between subjects with and without proteinuria. We used data of 721 men and 1,063 women, aged 20-79 years, in this cross-sectional investigation study. Parameters at muscle strength i.e. grip strength, leg strength and leg strength per body weight were evaluated. Proteinuria was measured by urine strip devices. Thirty five men (4.9%) and 27 women (2.5%) were diagnosed as having the proteinuria (+: 30 mg/dl) ≦). Leg strength and leg strength per body weight in men with proteinuria was significantly lower than that in men without proteinuria after adjusting for age. Grip strength in men with proteinuria was also lower than that in men without, but not at a significant level. However such link was not noted in women after adjusting for age. Among Japanese, proteinuria might be a modifiable factor of muscle strength in Japanese men.
Highlights
Chronic kidney disease (CKD) has become a public health problem in Japan and it is a major risk factor for the end stage renal disease, cardiovascular disease and premature death [1,2]
We firstly evaluated the link between proteinuria and muscle strength i.e. grip strength, leg strength and leg strength per body weight in Japanese
Anavekar et al showed that even mild renal disease was considered a major risk factor for cardio vascular disease (CVD) after myocardial infarction in 14527 patients with acute myocardial infarction [15]
Summary
Chronic kidney disease (CKD) has become a public health problem in Japan and it is a major risk factor for the end stage renal disease, cardiovascular disease and premature death [1,2]. We have previously showed in a cross-sectional study that the estimated glomerular filtration rate (eGFR) [4] in men with abdominal obesity and in women with hypertension was significantly lower than that in subjects without these components of metabolic syndrome [5]. In 2006 in Japan, levels of maximal oxygen uptake and muscle strength were recommended as exercise and physical activity reference quantity for health promotion 2006 (EPARQ2006) by the Ministry of Health, Labor and Welfare [8]. Resistance training has been advocated as the most suitable exercise for increasing muscle strength [9,10], the link between proteinuria and muscle strength in a large sample of Japanese has not yet been investigated. We investigated muscle strength evaluated by grip strength, leg strength and leg strength per body weight between subjects with and without proteinuria in Japanese
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