Comparison of medial preoptic, amygdala, and nucleus accumbens lesions on parental behavior in California mice (Peromyscus californicus)

Abstract

We have previously shown that medial preoptic area (MPOA) lesions disrupt parental behavior in both male and female California mice ( P. californicus). In the present study, we compare the effects of lesions in the MPOA, with those in the basolateral amygdala (BA) and nucleus accumbens (NA) on male and female parental behaviors in the biparental California mouse. A male or multiparous female from each male–female pair was given an electrolytic or sham lesion in the MPOA, BA, or NA and tested for parental responsiveness. Since female P. californicus show postpartum estrus, they were likely pregnant during parental testing. MPOA lesions produced deficits in both male and female parental behaviors, and BA lesions disrupted male, and to a lesser extent, female parental behavior. NA lesions produced mild effects on pup-retrieval in males and no effect on parental behavior in females. However, NA lesions incompletely destroyed the NA shell, the region most relevant for maternal behavior in rats, and should be investigated further. These results support a role for the MPOA and BA in both male and female parental behaviors.