Comparison of mean platelet volume (MPV) and red blood cell distribution width (RDW) between psoriasis patients and controls: A systematic review and meta-analysis.

Ping Yi,Jiao Jiang,Mingming Zhao,Yan Ding,Xing Wang,Haijing Wu,Zheyu Wang,Muhammad Tarek Abdel Ghafar

doi:10.1371/journal.pone.0264504

Abstract

The predictive role of hematological indexes of mean platelet volume (MPV) and red cell distribution width (RDW) has been demonstrated in cardiovascular disease concomitant with psoriasis. This meta-analysis is intended to assess whether MPV and RDW can also serve as biomarkers for the early diagnosis and disease severity assessment of psoriasis. 13 studies which enrolled 1331 psoriasis patients and 919 healthy volunteers were included after screening the search results from PubMed, Embase and the Cochrane Library since inception to Mar 14, 2020. MPV of psoriasis participants and their counterparts was assessed in 10 studies, and RDW was evaluated in 4 studies, while the disease severity was measured by the Psoriasis Area and Severity Index (PASI) in 11 studies. Random-effect model analysis was applied to calculate pooled standard mean difference (SMD) with 95% confidence interval (95% CI). Associations of MPV and RDW with the presence of psoriasis were demonstrated (MPV: SMD = 0.503, 95% CI: 0.242-0.765; RDW: SMD = 0.522, 95% CI: 0.228-0.817), but no statistically significant correlation of MPV and disease severity of psoriasis was found in meta-regression analysis (p = 0.208). Subgroup analysis revealed that the diagnosis value of MPV and RDW was consistent regardless of PASI and study type. Heterogeneity analysis between studies was implemented by chi-squared test and I2 statistics. Begg's and Egger's test were utilized for the evaluation of publication bias. The sensitivity analysis revealed no significant alteration no matter which study was excluded. MPV and RDW could serve as promising predictive diagnostic biomarkers of psoriasis.

Highlights

Psoriasis, a common chronic and systemic autoimmune inflammatory disease, is manifested with high individual heterogeneity symptoms, including recurrent scaly and burning skin patches, thick and dented nails, as well as swollen and stiff joints, complicated with a variety of other symptoms from cardiovascular, endocrine, digestive system and mental health [1]
mean platelet volume (MPV) of psoriasis participants and their counterparts was assessed in studies, and red cell distribution width (RDW) was evaluated in 4 studies, while the disease severity was measured by the Psoriasis Area and Severity Index (PASI) in studies
Associations of MPV and RDW with the presence of psoriasis were demonstrated (MPV: standard mean difference (SMD) = 0.503, 95% confidence interval (95% CI): 0.242–0.765; RDW: SMD = 0.522, 95% CI: 0.228–0.817), but no statistically significant correlation of MPV and disease severity of psoriasis was found in metaregression analysis (p = 0.208)

Summary

Introduction

A common chronic and systemic autoimmune inflammatory disease, is manifested with high individual heterogeneity symptoms, including recurrent scaly and burning skin patches, thick and dented nails, as well as swollen and stiff joints, complicated with a variety of other symptoms from cardiovascular, endocrine, digestive system and mental health [1]. Up to now, promising biomarker profiles of candidate gene expression (IL36G, CCL27, NOS2, C10orf, and S100A9) [4, 5], plasma proteins (desmoplakin, cytokeratin 17, polymeric immunoglobulin receptor, and complement C3, PI3, CCL22, IL-12B) [6, 7], inflammatory cytokines (adiponectin) [8], circulating microRNAs [9], GlycA [10] have been reported to assist the clinical diagnosis and reflect disease severity and inflammation state of psoriasis. Examinations of these diagnostic biomarkers are time-consuming and costly compared with blood routine. This meta-analysis is intended to assess whether MPV and RDW can serve as biomarkers for the early diagnosis and disease severity assessment of psoriasis

Methods

Results

Conclusion