Abstract
Lucanthone hydrochloride and TWSb, with and without dimercaptosuccinic acid, were given to school children harbouring S. haematobium during a period when transmission was not taking place. When followed up after 4 months, two of 15 children who had been given lucanthone hydrochloride in a dose of 10 mg./kg. body weight twice daily for 3 days were excreting viable ova, and one of 9, who had been given three injections of 0.5 gramme of TWSb, was passing viable ova. Dimercaptosuccinic acid reduced the incidence of headache, nausea and abdominal pain accompanying TWSb therapy, but it resulted in a much reduced cure rate. Side-effects with lucanthone hydrochloride were moderately severe, though all patients completed treatment. Neither drug is considered satisfactory for schistosomiasis control in East Africa in the regions described above.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Transactions of the Royal Society of Tropical Medicine and Hygiene
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
