Abstract
BackgroundThe purpose of this study was to evaluate the relationship between patterns of localized retinal nerve fiber layer (RNFL) defects and the degree of myopia in patients with normal-tension glaucoma (NTG).MethodsWe retrospectively reviewed medical records of patients with high myopia (42 eyes; spherical equivalent [SE] < −6.0 diopters [D]), low to moderate myopia (93 eyes; SE −6.0D ~ and −0.5D), and emmetropia (65 eyes; SE −0.5D ~ +0.5D), all of which were diagnosed as having NTG with localized RNFL defects. On RNFL photographs, the proximity of the RNFL defect to the center of the fovea (angle I) and the sum of the angular width of the defects (angle II) were determined. The patterns of localized RNFL defects were then compared with respect to differences in angles I and II.ResultsAngle I was significantly smaller in the high myopia group than in the low to moderate myopia group (p = 0.028) and the emmetropia group (p = 0.044), while angle II was significantly larger in the high myopia group compared with the low to moderate myopia group and the emmetropia group (p < 0.001, p = 0.007).ConclusionsAmong subjects with NTG, localized RNFL defects are wider and closer to the fovea in eyes with high myopia than those with low to moderate myopia or emmetropia.
Highlights
The purpose of this study was to evaluate the relationship between patterns of localized retinal nerve fiber layer (RNFL) defects and the degree of myopia in patients with normal-tension glaucoma (NTG)
MD of Humphrey C24-2 perimetry was significantly reduced in the high myopia group (−7.57 ± 4.04 dB) compared with the low to moderate myopia group (−5.15 ± 3.75 dB) and the emmetropia group (−4.38 ± 4.02 dB) (p = 0.014, p = 0.001)
Angle I, the proximity of the defect to the center of the fovea, was significantly smaller in the high myopia group (31.6 ± 11.9°) than in the low to moderate myopia group (40.8 ± 14.7°) and the emmetropia group (42.2 ± 14.2°)
Summary
The purpose of this study was to evaluate the relationship between patterns of localized retinal nerve fiber layer (RNFL) defects and the degree of myopia in patients with normal-tension glaucoma (NTG). In East Asian countries, the prevalence of myopia is high, and the number of new cases and the severity of the condition continue to increase [1]. An association between high myopia and glaucoma has been reported, with an increased prevalence of myopia in patients with ocular hypertension, primary open-angle glaucoma (POAG), and normal-tension glaucoma [2,3,4]. Imaging devices are commonly used to detect glaucomatous RNFL damage [5,6,7,8]. A visual field (VF) test has limitations in detecting glaucoma, especially in cases of high myopia due to myopic degeneration
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