Abstract
1. 1. Livers of Sprague-Dawley rats contain 30–100% more alcohol dehydrogenase activity than livers of Fischer-344 rats. 2. 2. When weight-matched rats from both strains are injected with the same dose of ethanol (1.2 g/kg), Sprague-Dawley rats achieve lower blood alcohol levels than Fischer-344 rats at all the time-points tested. 3. 3. Purified alcohol dehydrogenases from both strains of rats exhibit identical electrophoretic mobilities in SDS-polyacrylamide§ and in isoelectric focusing slab gels, pH optima, peptide maps, K m for ethanol, and capacities to bind monospecific rabbit antibodies. 4. 4. Quantitative differences in alcohol dehydrogenase activity between these strains of rats are due to differences in their liver alcohol dehydrogenase levels.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
