Abstract
The LigaSure vessel sealing system has been proposed to save operation time and reduce intraoperative blood loss for various surgeries. However, its usage for gastric cancer is still controversial. The aim of the present meta-analysis was to compare the effectiveness of LigaSure with conventional surgery in gastrectomy. Sources were retrieved from the Cochrane Library, MEDLINE, EMBASE, SCOPUS and Google Scholar until February, 2015. All randomized controlled trials comparing LigaSure with conventional surgery in curative gastric cancer resection were selected. After data extraction, statistics were performed by Review Manager 5.1 software. Three eligible randomized controlled trials were evaluated, with a total of 335 patients. The quality of the included trials was good, yet some methodological and clinical heterogeneity existed. There were no significant differences between the LigaSure and conventional groups in operative time (weighted mean difference [WMD], -22.95 minutes; 95% confidence interval [CI], [-59.75, 13.85]; P = 0.22), blood loss (WMD, -45.8 ml; 95% CI, [-134.5, 42.90]; P = 0.31), nor the incidence of surgical complications (odds ratio, 1.18; 95% CI, [0.68, 2.05]; P = 0.54). But there was a longer duration of hospital stay in LigaSure group (WMD, 1.41 days; 95% CI, [0.14, 2.68]; P = 0.03). All available randomized evidence has been summarized. LigaSure does not confer significant advantage over conventional surgery for curative gastric cancer resection. The usefulness of the device may be limited in gastrectomy. But, more trials are needed for further assessment of the LigaSure system for gastric cancer.
Highlights
Gastric cancer is one of the most common malignancies worldwide (Siegel et al, 2015)
There were no significant differences between the LigaSure and conventional groups in operative time, blood loss (WMD, -45.8 ml; 95% confidence interval (CI), [-134.5, 42.90]; P = 0.31), nor the incidence of surgical complications
There were a total of 335 patients: 160 participants were in the LigaSure group and 175 participants in the conventional surgery group
Summary
Gastric cancer is one of the most common malignancies worldwide (Siegel et al, 2015). Most lymphatic channels, vessels, and tissue bundles are ligated with suture material or thread to prevent bleeding and lymphatic leakage. As a result, it is often associated with a long surgical time and significant bleeding. The LigaSure vessel sealing system has been proposed to save operation time and reduce intraoperative blood loss for various surgeries. All randomized controlled trials comparing LigaSure with conventional surgery in curative gastric cancer resection were selected. LigaSure does not confer significant advantage over conventional surgery for curative gastric cancer resection. More trials are needed for further assessment of the LigaSure system for gastric cancer
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Asian Pacific journal of cancer prevention : APJCP
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
