Abstract
The unsaturated disaccharide isomers of chondroitin sulfate (CS) obtained by enzymatic digestion of the polysaccharide can be differentiated in mixtures by ion mobility MS (A) as well as pulsed-field gradient NMR (B).
Highlights
Glycosaminoglycans (GAGs) as building blocks of proteoglycans are important constituents of the extracellular matrix (ECM) of connective tissues
The repeating units are composed of b-1/3 linked uronic acid and N-acetylgalactosamine (GalNAc) and may vary in the type of the uronic acid, D-glucuronic acid (GlcA) or L-iduronic acid (IdoA), and in the location of the sulfo groups, resulting in a high diversity of possible building blocks in the polysaccharide chain
Polymeric chondroitin sulfate from bovine trachea and all solvents were purchased from Sigma-Aldrich (Deisenhofen, Germany)
Summary
Glycosaminoglycans (GAGs) as building blocks of proteoglycans are important constituents of the extracellular matrix (ECM) of connective tissues These unbranched acidic polysaccharides are omnipresent in mammals and play important roles, as structure lending components, for example, in skin or cartilage, and during the development of the central nervous system, wound healing processes, and biomolecular signaling. These large varieties of functions and the related diseases have been addressed in many recent reviews.[1,2,3,4,5].
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