Abstract
Summary In unanesthetized dogs with a pancreatic fistula, a highly purified secretin (Gastro intestinal Hormone Laboratory, Karolinska Institute, Stockholm, Sweden) was given intravenously and subcutaneously. After subcutaneous injections, the peak response per 15 min was smaller than after intravenous injections, but the total response lasted very much longer. The significant difference between the slopes of the dose-response curves for the two routes indicates that, in the range of doses chosen, subcutaneously injected secretin stimulates the secretion of more pancreatic juice than intravenously injected secretin. Pure secretin is a highly effective stimulant of pancreatic secretion by the subcutaneous route.
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