COMPARISON OF INTRATHECAL MIDAZOLAM VERSUS INTRATHECAL FENTANYL AS AN ADJUVANTS IN SPINALANAESTHESIA TO BUPIVACAINE FOR INFRAUMBILICAL SURGERIES, A RANDOMIZED INTERVENTIONAL CLINICAL STUDY

Abstract

Background- This study is regarding the use of non-opioid adjuvants to intrathecal local anesthetics. Opioids are commonly used as an adjuvant; however, the use of opioids is associated with potential respiratory depression and other side effects. The purpose of this study is to nd out nonopioid alternative as an adjuvant to local anesthetics for analgesia in spinal anesthesia. Methods- This study was conducted in SMS Hospital, Jaipur, Department of Anaesthesiology. 72 patients, scheduled to undergo different infraumbilical surgeries were chosen randomly and preanesthetic check-ups was done same day. Patients of either sex, age ranging between 20-60 years, belonging to ASAgrade 1 and II were chosen for study. Informed consent was obtained from each patient. Results- Mean duration of sensory and motor block in Group A and group B was 278.92,194.14 and 194.42,52.17 respectively(P<0.001S). Total duration of analgesia(min) was not signicant (P=0.137NS). Maximum number of the cases 91.67% in Group Awere observed in the 4score followed by 8.33% in 5 score. As compared to in other group B, maximum number of the cases were observed 61.11% in the 4. And followed by 30.56in5 and rest 8,33% were in score 6. this observation was statistically. Hypotension cases were observed in 13.88% of Group Aand lower 11.11% in Group B (p value = 1.00NS); Bradycardia cases were observed in 5.55% of Group A and 2.78% in Group B, also statistically not signicant (P = 1.000NS). Pruritis was observed only in group B (13.88%) also statistically signicant. Conclusion- Our study concluded that midazolam cause longer duration of motor and sensory block and visual analogue score is also lower postoperatively in initial hours, however, there was no difference in the total duration of effective analgesia between adjuvant intrathecal midazolam as compared to intrathecal fentanyl for patients undergoing infra umbilical surgery