Abstract
Background: The intranasal route is a reliable way to administer preanaesthetics and sedatives to children. The aim of present study was to compare the anxiolytic and sedative effects of intranasal dexemedetomidine and midazolam as a premedication in children with congenital heart disease undergoing cardiac surgery.. Patients and Methods: Fifty chidrens 2-12 years of age group of either sex with congenital heart disease undergoing cardiac surgery were randomly allocated into two groups. Group A-(n=25) - received intranasal dexmedetomidine as premedication.(0.1 µg/kg diluted in 2ml NS ) Group B- (n=25)- received intranasal midazolam as premedication. (0.2 mg/kg diluted in 2ml NS) Heart rate, mean arterial blood pressure and oxygen saturation were monitored upto30 minute after drug administration. The sedation score, anxiety score and child separation score were recorded until the child taken to the OR. The postoperative agitation score was also observed. Results and Conclusion: Premedication with intranasal dexmedetomidine attained significant and satisfactory sedation with better parental separation and lower anxiety levels without any adverse effects as compared with intranasal midazolam in children with congenital heart disease undergoing cardiac surgery.
Highlights
The intranasal route is a reliable way to administer preanaesthetics and sedatives to children
We found that anxiety score was lower in dexmedetomidine group (1.8±0.76) than midazolam group (3.16±0.69) at 30 minutes after intranasal premedication (p value < 0.001).Our results coincide with study by Medhat M
Messeha et al{10}.They concluded that premedication with intranasal dexmedetomidine (1±0.2) attained significant and satisfactory anxiety levels without any adverse effects as compared with intranasal midazolam (1.8±0.4) in children with simple congenital heart disease (ASD, VSD) undergoing cardiac catheterization (p value < 0.05).Ghali AM et al{13}did a comparison of intranasal dexmedetomidine versus oral midazolam as a preanesthetic medication in children
Summary
The intranasal route is a reliable way to administer preanaesthetics and sedatives to children. The aim of present study was to compare the anxiolytic and sedative effects of intranasal dexemedetomidine and midazolam as a premedication in children with. Group A-(n=25) - received intranasal dexmedetomidine as premedication.(0.1 μg/kg diluted in 2ml NS ). Group B- (n=25)- received intranasal midazolam as premedication. Mean arterial blood pressure and oxygen saturation were monitored upto[30] minute after drug administration. The sedation score, anxiety score and child separation score were recorded until the child taken to the OR.
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