Abstract
Objective: Insulin resistance (IR) means a reduced ability of insulin to stimulate glucose utilization. IR is related to cardiovascular disease (CVD) risk as the IR forms the basis for atherogenesis and acts as a major risk factor for atherosclerotic CVD.
 Methods: Total of 195 participants were recruited divided into three groups based on the presence of metabolic abnormalities as control Group I (with <3 components of metabolic syndrome [MS]), MS group as Group II (with any 3 components of MS), and severe MS as Group III (with more than three components of MS).
 Results: Results showed that fasting blood sugar (FBS) and glycated hemoglobin showed a significant difference between the groups (p<0.001), whereas fasting insulin and IR were higher in severe MS which showed statistically significant difference (p<0.001) in comparison with control and MS group.
 Conclusion: IR is one of the principal factors for the development of MS and further threw light that the increase in the IR level proportionately increases the severity of MS.
Highlights
insulin resistance (IR) means a reduced ability of insulin to stimulate glucose utilization [1]
IR is related to cardiovascular disease (CVD) risk as the IR forms the basis for atherogenesis and acts as a major risk factor for atherosclerotic CVD [3,4]
Observations showed significant difference (p=0.004) of fasting blood sugar (FBS) among the groups and in severe metabolic syndrome (MS) and MS, the FBS values were more in comparison with that of the control group, whereas the mean values of postprandial blood sugar (PPBS) recorded from the subjects did not show a significant difference (p=0.064) among themselves
Summary
Reflex compensatory hyperinsulinemia is seen in IR due to increased secretion of insulin from the beta-cells of the pancreas to maintain euglycemia [2]. IR is related to cardiovascular disease (CVD) risk as the IR forms the basis for atherogenesis and acts as a major risk factor for atherosclerotic CVD [3,4]. Increased levels of circulating free fatty acids resulted from adipose tissue form a connection between obesity and IR, and obesity forms the most important factor for insulin resistance (IR) [5,6]. MS is a constellation of diseases caused by several interconnected cardiometabolic risk factors such as hypertension, obesity, hyperglycemia, and dyslipidemia [8]. MS prevalence is increasing in Asia due to increased stress, less physical activity, high consumption of fast food, and changes in daily lifestyle [9]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Asian Journal of Pharmaceutical and Clinical Research
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
