Abstract
The use of small institutionally prepared heparin removal (HR) columns in conjunction with the prothrombin time (PT) and activated partial thromboplastin time (aPTT) has been suggested as an alternative to dilutional prothrombin times (DPT) of the Owren type for monitoring coumarin influence in the presence of heparin. The commercially available product Heparsorb® (TEAE cellulose) was studied in a parallel trial with me proven ECTEOLA microcolumns used in the initial descriptions of the PT/HR and aPTT/HR. The Heparsorb procedure was modified to eliminate the second centrifugation step by placing the tablet on a column support. This was the only departure from manufacturer's specifications. The TEAE cellulose tablet was found to be as effective as the ECTEOLA microcolumn in removing 10 units/mL of heparin from normal and coumarin-treated patient plasmas. The commercial product had the advantage of not requiring refrigeration. The accuracy of the Heparsorb procedure for routine anticoagulant monitoring is now being evaluated.
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