Comparison of Innovative and Traditional Cardiometabolic Indices in Estimating Atherosclerotic Cardiovascular Disease Risk in Adults.

Ya-Chin Huang,Chia-Yen Dai,Chao-Ling Wang,Jiun-Chi Huang,Chia-I Lin,Hsu-Han Chien,Yu-Yin Lin,Hung-Yi Chuang,Fu-Wen Liang

doi:10.3390/diagnostics11040603

Abstract

This study aimed to investigate the performance of innovative and traditional cardiometabolic indices, including body mass index (BMI), waist circumference (WC), Chinese visceral adiposity index (CVAI), visceral adiposity index, lipid accumulation product, a body shape index (ABSI), body roundness index, conicity index (CI), triglyceride-glucose (TyG) index, TyG-BMI, and TyG-WC, in estimating atherosclerotic cardiovascular disease (ASCVD) risk in 3143 Taiwanese adults aged 20–79 years. Elevated 10-year ASCVD risk was defined as ≥7.5% using the Pooled Cohort Equations. The performance of different indices in estimating elevated ASCVD risk was assessed by receiver operating characteristic (ROC) curves. In multivariate-adjusted logistic regression analyses, all cardiometabolic indices (p-value < 0.001) were significantly associated with elevated ASCVD risk in both genders, except for ABSI and CI in women. In particular, CVAI had the largest area under the curve (AUC) in men (0.721) and women (0.883) in the ROC analyses. BMI had the lowest AUC in men (0.617), while ABSI had the lowest AUC in women (0.613). The optimal cut-off value for CVAI was 83.7 in men and 70.8 in women. CVAI performed best among various cardiometabolic indices in estimating elevated ASCVD risk. CVAI may be a reliable index for identifying people at increased risk of ASCVD.

Highlights

Therapeutic techniques and prevention strategies advance in recent decades, atherosclerotic cardiovascular disease (ASCVD) remains the major leading cause of death worldwide [1,2]
>79 years were excluded from the study because ASCVD risk estimation is applicable for individuals with the age between 20 and 79 years [27,28]
The comparisons of characteristics between women with an ASCVD risk ≥7.5% and

Summary

Introduction

Therapeutic techniques and prevention strategies advance in recent decades, atherosclerotic cardiovascular disease (ASCVD) remains the major leading cause of death worldwide [1,2]. The increasing prevalence of diabetes, hypertension, dyslipidemia, overweight, and sedentary lifestyle as the global economy grows is believed to be the key elements contributed to ASCVD [3,4]. Among these factors, central obesity increases the cardiovascular risk through insulin resistance, secretion of adipokines, and pro-inflammatory proteins, leading to atherogenic endothelial dysfunction [5,6,7]. Central obesity and fat mass are modifiable factors and potentially treatment targets for reducing the burden of ASCVD [8]. Since BMI has its limitation of describing the distribution of the body fat [11], waist circumference (WC) can reflect visceral and central obesity better than BMI [12]

Objectives

Methods

Results