Abstract
The incidence of myopia is increasing worldwide, and the investigation on pathophysiology of myopia is becoming more important. This retrospective study aimed to compare the thicknesses of individual retinal layers between high-myopic and control eyes, and to evaluate the effects of age and sex on each retinal layer thickness. We assessed 164 subjects and divided them into two groups based on axial length (AL) (i.e., high-myopic group (AL ≥ 26 mm) and control group (AL < 26 mm)). Individual retinal layer thicknesses of five subfields in the macula were measured using automated retinal segmentation software packaged with the spectral-domain optical coherence tomography and were compared. In high-myopia group, the thicknesses of total retina and all individual retinal layers in central and entire perifoveal subfields were significantly thicker than the corresponding layers in control group after adjustment for ocular magnification (all P < 0.05). There were no significant effects of sex on individual retinal thicknesses, and age had less negative effects on the thicknesses of retina layers in high-myopic eyes than normal eyes. Axially elongated, non-pathologic highly myopic eyes had different structural features than control eyes, with significantly greater individual macular layer thicknesses independent of sex or age.
Highlights
The spectral domain optical coherence tomography (SD-OCT) device enables cross-sectional imaging of the retina
Considering that the worldwide trend of increasing incidence of myopic patients is relatively greater in Asian countries, our study could provide valuable insight into better understanding the distinguishing characteristics of high myopia compared with control eyes using SD-OCT segmentation analysis
best-corrected visual www.nature.com/scientificreports acuity (BCVA) value was converted into logMAR scale value for statistical analysis; the mean value was logMAR 0.09 ± 0.07 in the high-myopia group and logMAR 0.09 ± 0.06 in the control group (VA range with Snellen chart: 20/16 to 20/25 in both groups)
Summary
The spectral domain optical coherence tomography (SD-OCT) device enables cross-sectional imaging of the retina. It uses the interference patterns generated by low coherence light reflected by the retina and is a noninvasive tool for quantitative and qualitative measurement of the macula. Several studies have evaluated the effects of age and sex on retinal layer thickness in normal and myopic indivduals[19,20,21,22]. The primary aim of our study was to investigate and compare the thicknesses of individual retinal layers of the macula between highly myopic eyes and control eyes. We evaluated the effects of age and sex on thickness of each retinal layer in these groups
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
