Abstract
1. In vitro addition of cadmium chloride (CdCl 2) to a reaction mixture decreased the liver microsomal cytochrome P-450 level of the male guinea-pig. In contrast nickel chloride (NiCl 2) did not cause any alteration in the cytochrome P-450 level. 2. Neither CdCl 2 nor NiCl 2 produced any activity changes in the liver microsomal NADPH-cytochrome c reductase. 3. When the liver microsomes were preincubated in the presence of CdCl 2, metal-induced reduction increased as the time of preincubation progressed and attained its maximum reduction level at about 15 min. 4. In the case of NiCl 2, the maximal reduction level was attained at about 5 min. However, no changes were observed by metals in liver microsomal NADPH-cytochrome c reductase activity as the time of preincubation progressed. 5. After preincubation, the reduction of cytochrome P-450 achieved by CdCl 2 was stronger than that obtained by NiCl 2; as well as than that obtained by CdCl 2; without preincubation.
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