Abstract
Background: The pathogenesis of lung cancer includes the accumulation of m ultiple genetic abnormalities. The CREB-binding protein(CBP) is one of several transcriptional co- activators among various sequence-specific DNA-binding transcription factors. CBP is involved in a wide range of cellu lar activities, such as DNA repair, cell growth, differentiation, and apoptosis that are suspected of contributi ng to tumorigenesis. The goal of this study was to evaluate CBP expression in a series of human lung tissues containing nor mal epithelium, premalignant lesions(hyperplasia and dysplasia) and squamous cell carcinomas. Materials and Methods: Immunohistochemical staining was performed on formalin-fixed p araffin-embedded sections by use of a monoclonal anti-CBP antibody. CBP expression was co mpared in samples from 120 patients with premalignant and malignant histological types including 20 meta plastic specimens, 40 dysplastic specimens, and 60 squamous cell carcinomas in the lung.Results: CBP expression was seen in 35% (7/20) of the metaplastic speci mens. 65% (26/40) of the dysplastic specimens, and 70% (42/60) of the squamous cell carcinomas (p<0.05). Accor ding to celluar atypism, CBP expression was 50% (10/20) of the low-grade dysplastic specimens and 80% (16/20) of the hi gh-grade dysplastic specimens(p <0.01). By cellular differentiation, CBP expression was seen in 95% (19/20) of the well differentiated squamous cell carcinomas, 85% (17/20) of the moderately differentiated carcinomas and 30% (6/20) of t he poorly differentiated lesions (p <0.05).Conclusion: These results suggest that CBP may have an important role in m alignant transformation of precancerous lung lesions and may be a marker for malignancy. (Tuberc Respir Dis 2007; 63: 165-172)Key Words: CBP, Lung, Metaplasia, Dysplasia, Squamous cell carcinoma.Address for correspondence: Mi Kyung Kim, M.D.Department of Pathology, Chung-Ang University Yongsan Hospital, 65-207, Hangang Ro 3-ga, Yongsan-gu, Seoul, KoreaPhone: 82-2-748-9671, Fax: 82-2-795-6122E-mail: ladymkk603@yahoo.co.krReceived: May. 3. 2007Accepted: Aug. 23. 2007
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