Abstract
Egg specific IgE levels are frequently used in combination with skin-prick tests to guide clinical decisions and to monitor egg allergy evolution in children. We compared both Immulite and ImmunoCAP egg specific IgE assays in egg allergic children, and found a linear correlation between both assays with a mean Immulite:ImmunoCAP ratio of 3. This is relevant information for clinicans wishing to estimate values from one assay to the other, as most literature has been published using the ImmunoCAP system.
Highlights
Egg specific IgE levels are frequently used in combination with skin-prick tests (SPT) to guide clinical decisions and to monitor egg allergy evolution in children
Most reports on egg allergy have been using the ImmunoCAP (Phadia AB, Uppsala, Sweden) assay [3,4,5], which is a problem for the fraction of clinicians who do not have access to it, as their lab works with Immulite (Siemens Healthcare Diagnostics, Tarrytown, New York) for technical or administrative reasons
Hamilton et al [8] found a mean Immulite:ImmunoCAP ratio of 4.85 and a high coefficient of determination of 0.95 in children aged 1–16 with a history of egg allergy, which is comparable to our results
Summary
Egg specific IgE levels are frequently used in combination with skin-prick tests to guide clinical decisions and to moni‐ tor egg allergy evolution in children. Egg specific IgE levels are frequently used in combination with skin-prick tests (SPT) to guide clinical decisions and to monitor egg allergy evolution in children. The objective of this study was to directly compare Immulite and ImmunoCAP egg white-specific IgE assays and to determine whether their measurements can be applied equivalently and/or adapted to guide clinical management of egg allergic children.
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