Abstract
ObjectiveThe present in vitro study investigated if simulated daily use of hydroxyapatite-based gel (15% HAP) remineralizes early caries lesions as effective as weekly use of high fluoride (12,500 ppm) concentration gel, comparing them with artificial saliva alone.Materials and methodsThree tooth blocks were produced from each of 20 bovine teeth. Caries-like lesion was created on each block by 4-day demineralization in acidified gel. The blocks were randomized into three remineralization groups (20 blocks/group); Hydroxyapatite-based gel (Karex gelée, 15% HAP, fluoride-free), fluoride-based gel (Elmex gelée, 12,500 ppm F−), and artificial saliva (AS). Remineralization was conducted using pH-cycling model for 28 days with storage in AS. The pH cycling model consisted of 2 h demineralization once daily for all groups, and 3 min HAP gel application once daily, 3 min fluoride gel application once weekly, or remain in AS only respectively. Baseline and post-test mineral loss were quantified using microradiography.ResultsPaired t-tests (baseline vs. post-Test) indicated significant (p < 0.0001) remineralization in all groups. When compared against each other using Games-Howell’s multiple comparison test, no significant difference in remineralization was observed between the two gels, but both gels exhibited significantly (p < 0.001) higher percentage mineral gain (HAP:39 ± 7%; fluoride:41 ± 11%) than AS alone (6 ± 2%).ConclusionHydroxyapatite-based gel (15% HAP) was as effective as fluoride-based gel (12,500 ppm F−) in remineralizing initial caries lesion.
Highlights
Dental caries is an oral disease that affects millions of individuals, both children and adults, worldwide.[1]
This slice served as baseline for Cochrane review reported caries reduction of 21% when using fluoride gels compared to placebo gels.[19] determining the Pre-treatment transverse microradiography (TMR) parameter (mineral loss (Δz1) of the lesion before remineralization
The aims of the present in vitro study were to investigate if a The enhanced image of the microradiograph was analyzed under simulated daily use of a HAP-based oral care gel containing 15% standard conditions of light intensity and magnification and HAP remineralizes early caries lesions (1) more effectively than processed, along with data from the image of the step wedge, by artificial saliva alone, and (2) as effective as the weekly use of a the TMR program
Summary
Standard remineralization and demineralization solutions were prepared using previously published protocols.[28,29,30] The remineralization solution (artificial saliva) was composed of 3.8 ppm Mg2+ (MgCl2·6 H2O), 84.36 ppm PO43− (K2HPO4/KH2PO4) 50 ppm Ca2+ (calcium lactate), 0.05 ppm fluoride, 0.625 g/L KCl, 0.4 g/L carbox-. There was a decrease radiograms, the pattern and the extent of remineralization in percentage value from fluoride gel (40.765 ± 10.745) to artificial produced within each lesion by each treatment group was saliva (6.008 ± 2.623) with a mean decrease of 34.757, 95% C.I. examined and described by comparing the pre-test and post-test [28.528, 40.985], which was statistically significant (p < 0.001). Reminer- study demonstrated that the HAP oral care gel tested in the alization induced by the artificial saliva was not clearly obvious from the images (Fig. 3) These remineralization patterns were present study released calcium and phosphorus on application on tooth surfaces,[26,43] further highlighting the potential of this consistent in all specimens in their respective experimental group. The effectiveness of fluoride in remineralizing early caries lesions in the present study once again
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