Abstract
Purpose: Spontaneous cartilage regeneration following damage caused by traumatic injury or degeneration (osteoarthritis) is poor, necessitating cell-based therapy. The goal is to identify a progenitor population within the pool of chondrocytes, which can be expanded in culture; as well as retain the property to differentiate into hyaline cartilage in vivo. Such a population, when isolated from articular cartilage especially from the superficial layers using fibronectin adhesion assay, has been found.
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