Abstract
BackgroundCell therapy using Human Bone Marrow Stem Cells (HBMSCs) has been shown to improve heart function after a myocardial infarction. The harvesting technique involved with bone marrow stem cells is invasive and yields a low cell number. There is now an increasing interest in Human Adipose Derived Stem Cells (HADSCs) as they are abundant and readily accessible from liposuction material. The present study was undertaken to investigate if HADSCs are superior than HBMSCs in myocardial regenerative therapy.ResultsBoth HADSCs and HBMSCs proliferated in a time dependent manner, however, the proliferative ability of HADSC was greater than the HBMSCs. In addition, both cells differentiated to the osteoblast lineage confirming their multipotency, when treated with induction medium. Furthermore, treatment of both cells with 5‐AC resulted in positive immunostaining of cardiac markers, troponinI and connexin 43, however the expression of these markers was enhanced in HADSCs. This was further confirmed by western blot analysis, however 5‐AC treatment did not exhibit cell contraction or multinucleation.ConclusionThe data suggest that HADSCs may prove to be a more ideal type of cell for regenerative therapy in the future.
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