Abstract
Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) enables easy and accurate pathological assessment. Here, we compared and assessed the area of samples on glass slides for three needle types: a 19-gauge Franseen needle (Acquire, Boston Scientific, Natick, MA, USA), a 22-gauge Franseen needle, and a 19-gauge fine-needle aspiration (FNA) needle (EZ Shot 3 Plus; Olympus, Tokyo, Japan). Among patients with suspected pancreatic cancer, with a ≥20 mm tumor located in the pancreatic body and tail, and who underwent EUS-FNA or FNB between June 2018 and March 2020, 10 were randomly selected to test each needle. The areas of histological tissue and blood clot samples were measured using the BZ-X800 imaging software (Keyence Corporation, Osaka, Japan). Baseline patient characteristics and pathological sample data showed no significant differences among the needles. The 19-gauge Franseen needle obtained significantly more histological tissue samples than the 19-gauge conventional needle (p = 0.010) and 22-gauge Franseen needle (p = 0.008). Conversely, there was no significant difference between the 19-gauge conventional needle and 22-gauge Franseen needle (p = 0.838) in this regard. The 19-gauge Franseen needle could collect more samples than the other needles, contributing to giving a more precise pathological diagnosis and more information, including genomic profiling.
Highlights
Introduction iationsEndoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is a safe and efficient procedure for pancreatic masses [1,2]
There were were no no differences differences among among the the groups regarding the median area of blood clots or the blood clots area/total area
Groups regarding the median area of blood clots or the blood clots area/total area
Summary
The choice of needle depended patients were randomly selected to evaluate the three needles. The choice of needle de on the performance period. We used a 19-gauge conventional needle [11], followed pended on the performance period. Diagnostic accuracy of EUS-FNA for pancreatic for genetic been reported the diagnostic of EUS-FNA fo cancer is loweranalysis. To minimize potential confounding and selection biases the groups, included patients with suspected pancreaticpotential cancer with ferentamong puncture routeswe canonly affect the tissue acquisition. To minimize confound aing tumor of ≥20 biases mm located in the andwe tailonly of theincluded pancreas.patients with suspected pan andsize selection among the body groups, creatic cancer with a tumor size of ≥20 mm located in the body and tail of the pancreas. Procedure was performed as an in-patient procedure using a curved linear echoendoscope
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