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Abstract
Abstract Introduction: By increasing the scientific focus on myelination, identifying factors that influence the myelination is an important goal for brain health. There are some studies that regular exercise improves myelin sheath and neuronal regeneration. However, the effects of exercise intensities on the myelination remain unclear. Therefore, the purpose of this study was to compare the effect of high-intensity interval (HIIT) versus low-intensity continuous training (LICT) on myelin synthesis-related genes in hippocampus of C57BL/6 mice. Materials and methods: Male C57BL/6 mice (n = 30) were randomly assigned to 3 groups: control (C), Interval training (IT), and Continuous training (CT). Training programs on the treadmill were performed for 8 weeks and then, the hippocampus of animals was analyzed for the expression of myelin basic protein (MBP) and proteolipid protein (PLP) genes. Data were analyzed using ANOVA. Results: The result showed that HIIT program significantly increased the mRNA levels of MBP and PLP in comparison with LICT and Control groups (P 0.05). Conclusion: Our results showed that HIIT had a more efficient by improving the expression of MBP and PLP genes compared to LICT in the hippocampus.
Highlights
By increasing the scientific focus on myelination, identifying factors that influence the myelination is an important goal for brain health
Research in the past decade suggests that high-intensity interval training (HIIT) is more efficient to improve neurotrophic factors and is preferred in clinical populations due to its superior physiological adaptations compared to low-intensity continuous training [8, 9]
Our results showed that both training programs were increased transcript levels of myelin basic protein (MBP) and proteolipid protein (PLP)
Summary
By increasing the scientific focus on myelination, identifying factors that influence the myelination is an important goal for brain health. The purpose of this study was to compare the effect of high-intensity interval (HIIT) versus low-intensity continuous training (LICT) on myelin synthesis-related genes in hippocampus of C57BL/6 mice. Training programs on the treadmill were performed for 8 weeks and the hippocampus of animals was analyzed for the expression of myelin basic protein (MBP) and proteolipid protein (PLP) genes. Conclusion: Our results showed that HIIT had a more efficient by improving the expression of MBP and PLP genes compared to LICT in the hippocampus. Recent studies have shown that exercise training was significantly increased PLP expression and reduced demyelination in the exercised group compared with control in brain animals [6]. The aim of the present study was to compare the effect of high-intensity interval (HIIT) versus low-intensity continuous training (LICT) on myelin synthesis related genes in hippocampus of C57BL/6 mice
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