Comparison of high sensitivity troponin I and NT pro BNP as prognostic markers of major adverse cardiac events across spectrum of ischemic heart disease

Abstract

Background: In an era of a cardiovascular epidemic an imminent search for highly sensitive and specific markers for prognostication in ischemic heart disease have been sought. This study attempted to assess how high sensitive troponin I and NT pro BNP fare as prognostic markers for major adverse cardiac events across the spectrum of ischemic heart disease and hence estimate cardiovascular risk.Objective: To compare high sensitivity Troponin I and NT pro BNP as prognostic markers of major adverse cardiac events across the spectrum of ischemic heart diseases including SIHD, USA/NSTEMI and STEMI. Methods:112 subjects were chosen across the spectrum of ischemic heart disease with equal number of STEMI, USA/NSTEMI AND SIHD. Patients were recruited after satisfying the inclusion criteria and standard definitions as per recommendations and guidelines. Hs trop I and NT pro BNP values were obtained for all patients apart from other parameters. The patients in the study underwent treatment as per standard recommendations.. RESULTS: Hs Troponin I was a poor prognostic marker of overall/ cardiovascular mortality if the entire study population was taken into context with a P value=0.954 and 0.765 respectively for baseline and third hour values.