Comparison of high- and low-molecular-weight sensitizing agents causing occupational asthma: an evidence-based insight

Abstract

ABSTRACT Introduction The many substances used at the workplace that can cause sensitizer-induced occupational asthma are conventionally categorized into high-molecular-weight (HMW) agents and low-molecular-weight (LMW) agents, implying implicitly that these two categories of agents are associated with distinct phenotypic profiles and pathophysiological mechanisms. Areas covered The authors conducted an evidence-based review of available data in order to identify the similarities and differences between HMW and LMW sensitizing agents. A PubMed search was performed using the keywords ‘occupational asthma’ AND ‘molecular weight’ up to 31 August 2023 and was supplemented by additional specific searches in the authors’ personal digital bibliographic libraries. Expert opinion Compared with LMW agents, HMW agents are associated with a few distinct clinical features (i.e. concomitant work-related rhinitis, incidence of immediate asthmatic reactions and increase in fractional exhaled nitric oxide upon exposure) and risk factors (i.e. atopy and smoking). However, some LMW agents may exhibit ‘HMW-like’ phenotypic characteristics, indicating that LMW agents are a heterogeneous group of agents and that pooling them into a single group may be misleading. Regardless of the presence of detectable specific IgE antibodies, both HMW and LMW agents are associated with a mixed Th1/Th2 immune response and a predominantly eosinophilic pattern of airway inflammation. Large-scale multicenter studies are needed that use objective diagnostic criteria and assessment of airway inflammatory biomarkers to identify the pathobiological pathways involved in OA caused by the various non-protein agents.