Comparison of Hepatic, Renal and Inflammatory Biochemical Parameters in Mild and Severe Covid-19 Patients

Abstract

Background: Several studies have suggested that hepatic and renal abnormalities are seen in COVID-19 patients. So in this study; we are evaluating the hepatic, renal and inflammatory bio-makers in mild and severe group of COVID-19 patients. Objective: To evaluate and compare the hepatic, renal and some inflammatory biomarkers in mild and severe group of COVID-19 patients. Methods: It was a single-centric retrospective study. This study included a total number of 199 RT-PCR confirmedCOVID-19 patients. These patients were divided into the mild group (n=96) and severe group (n=103) depending on the requirement of intensive care unit. We evaluated and compared the hepatic, renal and some inflammatory biomarkers between the mild and severe groups. Statistical analysis was done using a statistical package for the social sciences (SPSS). Results: Out of 199 cases, 68.3% were male and 31.7% were female. The mean age of the study population was found to be 52.4±14.6 years. Statistically, a significant difference at 5%(p=0.001) was observed for creatinine, urea, direct bilirubin, ferritin, aspartate amino-transferase, total protein, and albumin levels between the mild and severe group except for uric acid, total bilirubin, alanine-transaminase, alkaline phosphatase and lactate dehydrogenase. Conclusion: Our study shows hepatic and renal abnormalities are observed in COVID-19 infection. However, the percentage of hepatic and renal abnormalities was more in the severe group compared to the mild group. Further extensive studies should be carried out with a larger population with multi-centric studies in Karnataka. Keywords: COVID-19, Hepatic, Renal