Abstract
The aim of this study was to compare health-related quality of life (HRQOL) between type 2 diabetic patients with and without locomotive syndrome, which is a risk for becoming bedridden because of deteriorating locomotive organs. A total of 135 patients with type 2 diabetes mellitus (69.2±10.2years) were enrolled in this cross-sectional study. HRQOL was evaluated by the Euro-QOL-5 (EQ-5D), and locomotive syndrome was evaluated by "loco-check," established the Japanese Orthopedic Association. Clinical data, such as anthropometric parameters, blood and urine examination results, blood pressure (BP), drug usage, and psychological distress, were analyzed. Average HbA1c in all patients was 7.2±1.0%, and 74 patients (54.8%) were identified as having the locomotive syndrome. EQ-5D scores were significantly lower in type 2 diabetic patients with locomotive syndrome than in those without locomotive syndrome, even after adjusting for age, sex, body mass index (BMI), and HbA1c. By the multiple regression analysis, locomotive syndrome and age were identified as determinant factors of HRQOL in type 2 diabetic patients. In type 2 diabetic patients, lower HRQOL was a characteristic feature of subjects with locomotive syndrome, even after adjusting for confounding factors. Prevention or management of locomotive syndrome may be beneficial for improving HRQOL in type 2 diabetic patients.
Highlights
Type 2 diabetes mellitus has become a public health challenge in Japan, as well as throughout the world
Psychological distress was measured by the K6 questionnaire [9,10,11], and healthrelated quality of life (HRQOL) was evaluated by the Euro-QOL5 dimensions (EQ-5D), as previously described [12,13,14,15,16]
We evaluated the prevalence of locomotive syndrome in patients with type 2 diabetes mellitus
Summary
Type 2 diabetes mellitus has become a public health challenge in Japan, as well as throughout the world. Nine and a half million Japanese have type 2 diabetes mellitus, according to the Ministry of Health, Labour and Welfare of Japan [1]. Modern lifestyles, such as reduced physical activity and higher calorie diets, have been shown to be closely associated with the increase in type 2 diabetes mellitus. Type 2 diabetes mellitus is associated with developing cerebrovascular disease and ischemic heart disease, reducing the healthrelated quality of life (HRQOL) [2, 3]. Reducing locomotive organs may be closely associated with lower physical activity and exercise performance.
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