Comparison of Haemodynamic Parameters and Recovery Profiles of Desflurane Versus Sevoflurane in Patients Undergoing Laparoscopic Cholecystectomy

Abstract

Introduction: Inhaled anaesthetics are the most widely used drugs for maintenance of general anaesthesia because of their ease of administration and predictable intraoperative and recovery characteristics. Newer inhalational agents such as Desflurane provide several advantages over the older inhalational agents. Desflurane has a very low blood-gas partition coefficient [about 30% less than Sevoflurane] and low oil-gas partition coefficient [about 64% less than Sevoflurane]. Objectives: Our main aim to conduct this study was to compare the hemodynamic parameters and recovery profiles after Desflurane vs. Sevoflurane anaesthesia in elective laparoscopic cholecystectomy patients. Materials and Methods: It was a comparative prospective randomized study conducted after consent from institutional ethical committee. Study included 80 ASA I-II patients aged between 20-60 years, of either sex scheduled for elective laparoscopic cholecystectomy. Patients were randomly divided into two groups of 40 patients each. Group ‘D' received Desflurane as anesthetic agent and Group ‘S' received Sevoflurane as anesthetic agent for maintenance of anesthesia. Hemodynamic parameters were observed perioperatively. Recovery profiles of patients were noted after giving reversal. Results were calculated using statistical tests. Results: Time required for eye opening, extubation, verbal response and to attain an Modified Aldrete score of ≥9 was significantly shorter in Group D as compared to Group S. Hemodynamic parameters [pulse, BP, SpO2] were comparable in both groups. Conclusion: Desflurane administration in patients undergoing Laparoscopic Cholecystectomy was associated with stable peri-operative hemodynamic parameters, faster early recovery and not significantly higher side effects.