Abstract
BackgroundTo compare the glaucoma diagnostic ability of the ganglion cell-inner plexiform layer (GCIPL) thickness depending on the range around the fovea using wide-angle, swept-source optical coherence tomography (SS-OCT).MethodsWe compared the glaucoma diagnostic utility of GCIPL parameters across multiple regions while centered on the fovea. In a wide-angle scan, the GCIPL for each 1-mm2 grid square of a 12 × 9 mm2 scan resulted in 108 data points. With respect to the range of the GCIPL measurements around the macula, the wide-angle scan images were classified into three zones. Zone 1 was defined as a narrow area; zone 2 was defined as a mid-sized area; and zone 3 was defined as a wide area. We recorded the quadrant GCIPL thickness, average, and minimum quadrant GCIPL within each zone. The areas under the receiver operating characteristic (AUROCs) curves were calculated to evaluate the glaucoma diagnostic utility.ResultsSixty-one eyes with glaucoma and 59 normal eyes were assessed. The minimum and average GCIPL measurements in zones 1–3 in eyes with glaucoma were significantly lower than those in normal eyes (P < 0.001). The AUROCs for the minimum and inferotemporal GCIPL in zone 1 and the inferotemporal GCIPL thickness in zone 2 were greater than 0.9 (0.945, 0.931, and 0.918, respectively).ConclusionsWide-angle scanning using SS-OCT will contribute to improvements in the detection of glaucomatous damage. The minimum and inferotemporal GCIPL in zone 1 may be more useful for detecting glaucoma than those in the conventional area.
Highlights
To compare the glaucoma diagnostic ability of the ganglion cell-inner plexiform layer (GCIPL) thickness depending on the range around the fovea using wide-angle, swept-source optical coherence tomography (SS-OCT)
We investigated correlations and agreement among the 6mm-diameter GCIPL parameters derived via the spectral domain optical cohrerence tomography (SD-OCT) technique, which were based on the Early Treatment Diabetic Retinopathy Study (ETDRS) area and GCIPL parameters from zone 2
We evaluated the diagnostic utility of the GCIPL measurements from zone 1, zone 2, and zone 3 for differentiating glaucoma from normal eyes
Summary
To compare the glaucoma diagnostic ability of the ganglion cell-inner plexiform layer (GCIPL) thickness depending on the range around the fovea using wide-angle, swept-source optical coherence tomography (SS-OCT). GCIPL assessment with commercially-available spectral domain optical cohrerence tomography (SD-OCT) tools has become a standard clinical approach; this technique has several limitations with respect to the precise GCIPL parameter measurements that are needed to diagnose glaucoma. This protocol relies on the use of a fixed, 6-mm-diameter circular device that was developed not to measure GCIPL thickness but rather to diagnose and monitor significant macular edema in cases of diabetic retinopathy. With this tool, investigators can assess specific GCIPL parameters in a wide area of the macula and evaluate GCIPL changes in a particular region of the macula
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