Abstract
To determine the association between high hemoglobin with gestational diabetes mellitus (GDM) and preeclampsia in pregnant women in the first trimester. This cohort study was conducted among 973 pregnant women who started their antenatal booking in the first trimester (first 14 weeks of gestation). Women with first-visit high Hb levels (> 12.5 g/L) on first visit of the pregnancy period were selected as the study group and were compared with those who had normal Hb value (< 12.5 g/L) as controls. Adverse pregnancy outcomes including preeclampsia and GDM were compared between the two groups. Complete obstetric records of 448 women with high Hb levels and 486 women with normal Hb levels were studied. The follow up showed that the women with high Hb levels had significantly higher rates of preeclampsia and GDM than those with normal Hb levels; the risks were 5.4 (95% cl; 2.8 to 10.5) and 3.7 (95%cl; 2.2 to 6.4), respectively. This study found that high Hb in the first trimester is associated with higher risk of subsequent preeclampsia and gestational diabetes mellitus (GDM).
Highlights
Toxemia of pregnancy is a serious disorder that may occur from the 20th weeks of gestation up to seven days after delivery
This study showed that the risk for gestational diabetes in pregnant women with high hemoglobin level was 3.7 times more than the obtained results with pregnant women with normal hemoglobin
The relative risk in high hemoglobin group was 4.3 times more than the normal hemoglobin group. These results were similar to findings in our study in which the rate of preeclampsia was 11.1 in high hemoglobin group versus 2.1 in the group who had normal hemoglobin levels
Summary
Toxemia of pregnancy (pre-eclampsia) is a serious disorder that may occur from the 20th weeks of gestation up to seven days after delivery. It can cause vasoconstriction, and may result in increase. 1. Ferdous Mehrabian, MD, Associate Professor of Obstetrics & Gynecology, Obstetrics & Gynecology Department, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. 2. Seyyed Mohammad Hosseini, MD, Physician, Obstetrics & Gynecology Department, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. High level of hemoglobin is the evidence of adequate nutrition and health. High level of hemoglobin is dangerous and this will be always monitored by caregivers
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