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Abstract
BackgroundOur purpose is to examine the relationship of Health related quality of life measured by EORTC QLQc30, QLQ-LC13; FACT-L, LCSS, Eq5D) with survival in advanced lung cancer patients. A total of 299 Lung Cancer (LC) patients were, included in this national multicenter Project entitled of “the LC Quality of Life Project (AKAYAK). Baseline scores were analyzed by using Cox’s proportional hazard regression to identify factors that influenced survival. Univariate and multivariate models were run for each of the scales included in the study.ResultsMean and median survival were 12.5 and 8.0 months respectively. Clinical stage (as TNM), comorbidity; symptom scales of fatigue, insomnia, appetit loss and constipation were associated with survival after adjustment for age and sex. Global, physical and role functioning scales of QLQc30; physical and functional scales of LCS and TOI of the FACT-L was also associated with survival. Mobility and Usual activities dimensions of the Eq5D; Physical functioning and the constipation symptom scale of the QLQ-c30; and LCS and TOI scores of the FACT-L remained statistically significant after adjustment. LC13 and LCSS scales were not predictors of survival.ConclusionsHRQOL serves as an additional predictive factor for survival that supplements traditional clinical factors. Besides the strong predictive ability of ECOG on survival, FACT-L and the Eq5D are the most promising HRQOL instruments for this purpose.
Highlights
Our purpose is to examine the relationship of Health related quality of life measured by EORTC QLQc30, QLQ-LC13; FACT-L, Lung Cancer Symptom Scale (LCSS), Eq5D) with survival in advanced lung cancer patients
The objective of this study was to examine the prognostic value of baseline Health-related quality of life (HRQOL) for survival in any type of Lung cancer (LC) using well-known self-assessment tools of HRQOL in lung cancer
HRQOL and performance scales were completed at baseline for all patients regardless of the treatment type
Summary
Our purpose is to examine the relationship of Health related quality of life measured by EORTC QLQc30, QLQ-LC13; FACT-L, LCSS, Eq5D) with survival in advanced lung cancer patients. Herndon et al 1999; Polanski et al 2016; Ganz et al 1991; Eton et al 2003; Bernhard et al 1996; DharmaWardene et al 2004; Reck et al 2012; Hwang et al 2004; Sloan et al 2012; Qi et al 2009; Kaasa et al 1989; Naughton et al 2002; Nowak et al 2004; Braun et al 2011; Nishiyama et al 2006; Movsas et al 2009) These studies, either reviews (Gotay et al 2008; Mannion et al 2014; Guyatt et al 1993) or longitudinal design studies, found that baseline HRQOL was a prognostic indicator of survival. A diseasespecific measure may provide more detailed outcome information and so may be more relevant to patients and clinicians (Guyatt et al 1993), it was stated that the overall impact of functioning and well-being may be missed by using only a disease-specific measure (Coons and Shaw 2005)
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