Comparison of gene regulatory networks using adaptive neural network and self-organising map approaches over Huh7 hepatoma cell microarray data matrix

Abstract

Construction of gene regulatory network GRN is very important as it governs the expression levels of biomolecules in microarray data. In this article, we have developed GRNs by adaptive neural network ANN and self-organising map SOM approaches over Hepatitis C virus infection effect on Huh7 hepatoma cell microarray time series data. We then compared GRNs for the best performance analysis. We used fuzzy C-means clustering method to cluster the normalised dataset and then cluster centres are identified. After constructing GRNs within cluster centres, we analysed that SOM topology results a better performance providing minimum error to construct the GRN from sample data.