Abstract
Gastrointestinal pH as a function of time was recorded for 4 beagle dogs and 10 human subjects using radiotelemetric pH measuring equipment. Results indicated that in the quiescent phase, gastric pH in the dogs (mean=1.8 ± 0.07 SEM) was significantly (p<0.05) higher than in humans (1.1 ± 0.15). No significant difference in the time for the pH monitoring device to empty from the stomach was noted for the two species (99.8 ± 27.2min for dogs, 59.7 ± 14.8min for humans, p>0.05). The fasting intestinal pH in dogs was consistently higher than in humans, with an average canine intestinal pH of 7.3 ± 0.09 versus 6.0 ± 0.14 for humans. The implication of these observations for extrapolation of drug absorption data from dogs to humans are discussed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
