Comparison of Gastro Retention Time and <i>in vitro</i> Release Profile studies of Ciprofloxacin HCl from Co-matrix Tablets of Hydrophilic Polymers

Abstract

Controlled release co-matrix tablets of Ciprofloxacin HCl were prepared with different types of bioadhesivepolymers e.g. Methocel K4M, Methocel K 15M CR and Methocel K 100LV, Povidone K-30, and Xanthangum. Tablets prepared by direct compression method were subjected to in-vitro drug dissolution study for 8 hours ina simulated gastric fluid media using USP dissolution apparatus II with 50 rpm at 37±0.5ºC. The bio-adhesiveproperty was investigated in terms of retention time following in-vitro wash-off method. The concentrations ofpolymers were varied to investigate whether these variations can cause any change in release of Ciprofloxacin HClmolecule and bio-adhesion property or not. In most of the cases it is found that Methocel K4M and MethocelK100LV based co-matrix tablets release greater percentage of active drug than Methocel K15M CR based co-matrixtablets. Bio-adhesive strength of Methocel K15M CR and Xanthan gum based co-matrix tablets was proved to bemaximum followed by Methocel K4M and Xanthan gum based co-matrices. Whereas Methocel K100LV andXanthan gum based co-matrices showed little or poor muco-adhesion. Methocel K4M, K15M CR and Xanthan gumbased formulations showed nearly zero-order release, on the other hand Methocel K100LV and Xanthan gum basedformulation showed a burst release within one hour of dissolution. Finally it was revealed that Xanthan gum providedoptimum bio-adhesion functioning as a synergist in co-matrices and comply the USP specification as a most suitablecontrolled release polymer.Key words: Gastro retention time; Direct Compression; Ciprofloxacin HCl; Methocel K4M; Methocel K15M CR;Methocel K100LV; Xanthan gum.DOI: 10.3329/dujps.v8i1.5338Dhaka Univ. J. Pharm. Sci. 8(1): 67-73, 2009 (June)