Comparison of gastric responses to small intestinal resection and bypass in rats.

Abstract

Hypergastrinemia has beenjtiund in patients with short bowel syndrome but not in patients with jejunoileal bypass. To clarzfy the divergent gasi it was the only measured parameter which did not increase after small intestinal resection. The data show that, in contrast with jejunoileal bypass, massive small intestinal resection in the rat causes a signa$cant increase in serum gastrin with concomitant trophic changes ,in the stomach. We conclude that the small intestine is an important regulator of gastric function, even when removed~from intestinal continuity and left in situ 411 intestinal bypass.