Abstract
Summary Experimental aerogenic infection of guinea pigs with small numbers of bacterial cells from freeze-dried BCG vaccine preparations has revealed that one preparation was greatly superior to four others. It was shown that killing guinea pigs three weeks after challenge, with virulent tubercle bacilli by aerogenic infection provides a rapid test of the efficacy of an immunizing agent. A strong correlation of a positive tuberculin reaction with immunity following aerogenic vaccination with small numbers of BCG was demonstrated.
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