Comparison of fractional exhaled nitric oxide levels measured using the NIOX VERO and NOA 280i

Abstract

Fractional exhaled nitric oxide (FeNO) is a type 2 biomarker of eosinophilic airway inflammation and predicts the likelihood of corticosteroid responsiveness in patients with eosinophilic asthma. 1 Dweik R.A. Boggs P.B. Erzurum S.C. et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med. 2011; 184: 602-615 Crossref PubMed Scopus (1805) Google Scholar , 2 Robinson D. Humbert M. Buhl R. et al. Revisiting type 2-high and type 2-low airway inflammation in asthma: current knowledge and therapeutic implications. Clin Exp Allergy. 2017; 47: 161-175 Crossref PubMed Scopus (247) Google Scholar Several devices are available to measure FeNO levels for research purposes or in clinical practice worldwide, including the Sievers Nitric Oxide Analyzer (NOA 280i; GE Analytical Instruments, Boulder, Colorado), a stationary chemiluminescence analyzer, and the NIOX VERO (Aerocrine AB, Solna, Sweden), a portable electrochemical analyzer. The NIOX VERO is a new FeNO measurement device that is intended to replace the NIOX MINO, a previous portable electrochemical analyzer from the same manufacturer. [3] National Institute for Health and Care Excellence. Measuring fractional exhaled nitric oxide concentration in asthma. NICE diagnostics guidance 12. www.nice.org.uk/dg12. Accessed August 24, 2017. Google Scholar Some reports have compared the NOA 280i with the NIOX MINO. 4 Kim S.H. Moon J.Y. Kwak H.J. et al. Comparison of two exhaled nitric oxide analyzers: the NIOX MINO hand-held electrochemical analyzer and the NOA280i stationary chemiluminescence analyzer. Respirology. 2012; 17: 830-834 Crossref PubMed Scopus (33) Google Scholar , 5 Maniscalco M. de Laurentiis G. Weitzberg E. et al. Validation study of nasal nitric oxide measurements using a hand-held electrochemical analyser. Eur J Clin Invest. 2008; 38: 197-200 Crossref PubMed Scopus (41) Google Scholar However, potential differences between the NOA 280i and NIOX VERO remain unclear. In this cross-sectional study, we compared FeNO levels measured using the NOA 280i and NIOX VERO.