Comparison of follicular fluid concentrations of anti-mullerian hormone, bone morphogenetic protein 15 and transforming growth factor ß1 between modified natural and stimulated in-vitro fertilization cycles.

Abstract

Analysis of biochemical characteristics of follicular fluid (FF) can serve as a non-invasive method for the prediction of oocyte and embryo quality. The aim of the present study was to compare concentrations of anti-mullerian hormone, bone morphogenetic protein 15 and transforming growth factor ß1 in FF of follicles giving rise to high quality embryos between natural and stimulated IVF cycles. Concentration of BMP-15 was significantly higher and concentration of TGF-ß1 was significantly lower in stimulated IVF cycles. Concentrations of markers of oocyte and embryo quality were significantly different between natural and stimulated IVF cycles. This could be the cause for lower pregnancy rates in natural IVF cycles.