Comparison of fluconazole release from hydrogels with Syntalen MP and Syntalen KP and from hydrophilic cream

Abstract

Fluconazole is popular antifungal medicine, usually used per os in Candida spp. infections of the skin and mucous membranes, pityriasis versicolor, candidiasis organs, and also in the prophylaxis of fungal infections in patients with cancer and AIDS. There are attempts of formulation of the different forms of drug because of many side effects of fluconazole in oral administration. These are eye drops, injections and semisolid skin preparations. Thus, the aim of the study was preparing two hydrogels with Syntalen MP and Syntalen KP and hydrophilic cream, containing 1% of fluconazole and comparing the release of the substance from obtained preparations. At the beginning, gels and hydrophilic cream have been subjected to physical tests such as: slip and spreadability. Further, their rheological properties were evaluated. In the slip and spreadability tests, the cream had the best parameters, the rheological tests showed pseudoplastic character of flowing of gels and plastic flowing of the cream. All these three preparations showed the thixotropy. The release studies, conducted using the extracting chamber (according to FP IX) in Paddle Apparatus showed that the amount of released substance from gels is about two times bigger than from the cream, but the releasing from the gel with Syntalen MP is slightly better than from the gel with Syntalen KP.