Abstract
The utilization of co-processed excipients (CPEs) represents a novel approach to the preparation of orally disintegrating tablets by direct compression. Flow, consolidation, and compression properties of four lactose-based CPEs—Cellactose® 80, CombiLac®, MicroceLac® 100, and StarLac®—were investigated using different methods, including granulometry, powder rheometry, and tablet compaction under three pressures. Due to the similar composition and the same preparation technique (spray drying), the properties of CPEs and their compacts were generally comparable. The most pronounced differences were observed in flowability, undissolved fraction after 3 min and 24 h, energy of plastic deformation (E2), ejection force, consolidation behavior, and compact friability. Cellactose® 80 exhibited the most pronounced consolidation behavior, the lowest values of ejection force, and high friability of compacts. CombiLac® showed excellent flow properties but insufficient friability, except for compacts prepared at the highest compression pressure (182 MPa). MicroceLac® 100 displayed the poorest flow properties, lower ejection forces, and the best mechanical resistance of compacts. StarLac® showed excellent flow properties, the lowest amounts of undissolved fraction, the highest ejection force values, and the worst compact mechanical resistance. The obtained results revealed that higher compression pressures need to be used or further excipients have to be added to all tested materials in order to improve the friability and tensile strength of formed tablets, except for MicroceLac® 100.
Highlights
This study provides a comprehensive evaluation of four commercially available co-processed excipients (CPEs) based on lactose—Cellactose® 80 (CE), CombiLac®
(CO), StarLac® (ST), and MicroceLac® 100 (MI). All these materials were manufactured by the spray drying (SD) method; differences in composition are a crucial factor in distinguishing their behaviors
The flow, viscoelastic, and compression properties of four commercially available co-processed excipients (Cellactose® 80, CombiLac®, MicroceLac® 100, and StarLac® ), prepared by spray drying of lactose with other pharmaceutical excipients, were investigated in this experimental study
Summary
The direct compression of active pharmaceutical ingredients (APIs) mixed with different types of excipients is still the most preferred method of tablet preparation. This process is time and cost efficient, the insufficient content, mass uniformity, and low mechanical resistance of tablets represent formulation problems that need to be overcome. Single-component excipients often do not provide the required physicochemical properties to allow specific APIs to be adequately formulated by direct compression [1,2]. The development of new excipients and their combinations has gained increasing attention
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