Abstract
Background: Fine needle aspiration cytology and core needle biopsy are reliable procedures for breast cancer detection. Core needle biopsy is an established alternative to surgical biopsy for diagnosis and prognostication. However, there may be a concern that core needle biopsy may be less reliable than excisional biopsy. The aim of this study was to compare the cytological/core needle biopsy finding with excisional histopathological diagnosis and determine their hormonal status.
 Materials and Methods: A prospective study of 65 patients was conducted after obtaining a detailed clinical data. The comparison of the fine needle aspiration cytology/core needle biopsy finding with excisional histopathological diagnosis of breast malignancy was carried out after data analysis. Their ER, PR and HER-2/neu status was also studied in available cases.
 Results: Out of the 65 cases of breast malignancy, 69.2% of cases had undergone fine needle aspiration, 60% cases core needle biopsy and 93.8% cases excisional biopsy. The most common carcinoma was invasive carcinoma of no special type. The diagnostic accuracy of fine needle aspiration and core needle biopsy was almost equal, however, core needle biopsy could assess the histological typing and biomarker status. The hormonal status was assessed in 69.23% cases, among them 35.6% cases were triple negative carcinomas.
 Conclusions: Core needle biopsy was superior to fine needle aspiration cytology in the diagnosis of breast lesions in terms of diagnostic accuracy. Thus, our result provides valuable prognostic information to guide the decision-making process for the treatment of a patient with invasive carcinoma.
Highlights
Breast cancer is a heterogeneous disease at the clinical, morphological and molecular levels with varied responses to therapy
The age of the patients with suspicion of breast carcinoma ranged from 26 years to 82 years with a mean age of 47.38±11.9 years
This study reflects the comparability between FNAC and core needle biopsy (CNB) in the diagnosis of breast carcinoma considering the histological diagnosis from the excision specimen being the gold standard
Summary
Breast cancer is a heterogeneous disease at the clinical, morphological and molecular levels with varied responses to therapy. The role of Fine needle aspiration (FNA) is a less traumatic alternative to core needle biopsy (CNB) and the main goal is to confirm benign clinical and radiological findings in order to avoid unnecessary surgery.[1,2] Advantage of CNB is the ability to diagnose invasiveness and allow the patient to undergo a single operation including sentinel node biopsy in cases diagnosed as invasive. Fine needle aspiration cytology and core needle biopsy are reliable procedures for breast cancer detection. Core needle biopsy is an established alternative to surgical biopsy for diagnosis and prognostication. The aim of this study was to compare the cytological/core needle biopsy finding with excisional histopathological diagnosis and determine their hormonal status
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
